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Comment by janice1999

8 hours ago

Paper: https://pubmed.ncbi.nlm.nih.gov/38692517/

> Recellularization via electroporation therapy (ReCET) is a novel endoscopic procedure that uses electroporation to induce cellular apoptosis and subsequent reepithelization.

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janice1999

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arcticbull  8 hours ago

... plus GLP-1.

GLP-1s baseline eliminate insulin for about ~40% of people. This boosts that number to 86%.

Note that Tirzepatide also reduces the chance of developing type 2 in the first place by 94%, and I suspect that newer generation receptor agonists will see higher insulin discontinuation rates in general.

Very cool stuff all around. Might finally be able to put this whole obesity-and-diabetes thing to bed.

  • metadat  7 hours ago

    Tirzepatide side effects sound pretty nasty, though less so than dying in a diabetic coma.

    https://en.wikipedia.org/wiki/Tirzepatide

    • phil21  6 hours ago

      The side effects are wildly exaggerated due to the current social media discourse on the subject.

      I am in a pretty close knit community of 100s of people on the subject and while the side effects should not be discounted, figuring out ways to properly take the medication more or less eliminates them completely for nearly everyone.

      The current dosing and schedules of the drug (and all GLP-1s for that matter) are largely an effect of what was tested during trials and not what will end up being most effective a decade from now. The rest of it is patient compliance and liability from drug manufacturers.

      The most obvious two things to point at are that the half life of Tirzepatide is 5 days while the prescriptions are for 7 day intervals for ease of use. The other would be the rather large jumps in dosing (2.5mg per step) available in injector pen forms and prescribed.

      Some bleeding edge doctors are willing to take the risk to go outside dosing and schedule guidelines, but not many.

      Even then, the side effects seem to be rather minor compared to obesity or T2D and few and are far between.

      I also had similarly reactions to the topic before I started to really look into it and dig deeper. I firmly believe these medications will change society at a level only antibiotics have so far.

      5 replies →

    • tssva  7 hours ago

      The side effects are usually short lived. I'm on tirzepatide and had some mild digestive issues for the 1st 3 - 4 weeks and haven't had any since then. My side effects when starting metformin were worse.