Comment by phil21

Fair on the doctor part - I've found doctors to be pretty reluctant to go off label for such things like dosing schedule on these new drugs. YMMV.

Re: the half-life, I generally agree - however at low dosing, a half-life calculator seems to coincide with some folks experience with side effects - especially starting out initially. Once the dosing levels go up, the impact is much less - but even I at my peak weight loss at a mid-dosing level could tell a difference in hunger levels if I had to wait a few days due to travel or whatnot.